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Index > Protein center > Hif3a(Gene name) > Mouse
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  • Hif3a (Gene name),
  • Hypoxia-inducible factor 3-alpha (Protein name ),  HIF3A_MOUSE from NCBI database.
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  • Gene name:
    Hif3a(Mop7);
    Protein name:
    Hypoxia-inducible factor 3-alpha(HIF-3-alpha;HIF3-alpha);
    Alternative:
    HIF3-alpha-1;Basic-helix-loop-helix-PAS protein MOP7;Member of PAS protein 7;Inhibitory PAS domain protein(IPAS);
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Heterodimerizes with ARNT. Interacts via the oxygen-dependent degradation domain (ODD) with the beta domain of VHL.
    Function:
    Involved in adaptive response to hypoxia. Suppresses hypoxia-inducible expression of HIF1A and EPAS1. Binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters. The complex HIF3A-ARNT activates the transcription of reporter genes driven by HRE. Isoform 2 has a dominant-negative function of inactivating HIF1-mediated transcription. Isoform 2 attenuates the binding of HIF1 to hypoxia-responsive elements (HRE), thus inhibiting HRE-driven transcription. Hypoxia induces down-regulation of isoform 2, leading to activation of HIF1A in hypoxia. Conversely, upon restoring normoxia, the expression of isoform 2 increases and thereby secures an inhibition of HIF1A activity (By similarity). May be a negative regulator of hypoxia-inducible gene expression in the kidney. May be involved in renal tumorigenesis. Functions as an inhibitor of angiogenesis in the cornea.
    Subcellular Location:
    Nucleus Cytoplasm
    Protein Attributes:
    Sequence length:
    662
    Sequence:
    50:
    MDWDQDRSNT | ELRKEKSRDA | ARSRRSQETE | VLYQLAHTLP | FARGVSAHLD | 
    100:
    KASIMRLTIS | YLRMHRLCAA | GEWNQVEKGG | EPLDACYLKA | LEGFVMVLTA | 
    150:
    EGDMAYLSEN | VSKHLGLSQL | ELIGHSIFDF | IHPCDQEELQ | DALTPRPNLS | 
    200:
    KKKLEAPTER | HFSLRMKSTL | TSRGRTLNLK | AATWKVLHCS | GHMRAYKPPA | 
    250:
    QTSPAGSPRS | EPPLQCLVLI | CEAIPHPASL | EPPLGRGAFL | SRHSLDMKFT | 
    300:
    YCDERIAEVA | GYSPDDLIGC | SAYEYIHALD | SDAVSRSIHT | LLSKGQAVTG | 
    350:
    QYRFLARTGG | YLWTQTQATV | VSGGRGPQSE | SIICVHFLIS | RVEETGVVLS | 
    400:
    LEQTEQHTRR | PPRLSASSQK | GIPGNSVDSP | APRILAFLHP | PALSEASLAA | 
    450:
    DPRRFCSPDL | RRLMAPILDG | PPPAATPSTP | QATRRPQSPL | PADLPDKLTV | 
    500:
    GLENAHRLST | AQKNKTVETD | LDIAQDPDTL | DLEMLAPYIS | MDDDFQLNSS | 
    550:
    EQLPKVHRRP | PRVARRPRAR | SFHGLSPPIP | EPSLLPRWGS | DPRLNCSSPS | 
    600:
    RGDRPTASLM | PGTRKRALAQ | SSEDKGLELL | ETKPPKRSPR | LEPGSFLLPP | 
    650:
    LSLSFLLQGR | QLPGNQQDPR | APLVHSHEPL | GLAPSLLSLC | QHEETVQPRN | 
    662:
    RFPPAAGLGQ | TH
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    KEGG:
    String:
    SMR:
    Pfam:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse HIF-3-alpha
    Cat.:
    E10271h
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Mouse HIF-3-alpha
    Cat.:
    E10271r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Mouse HIF-3-alpha
    Cat.:
    E10271m
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse HIF-3-alpha
    Cat.:
    U10271m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse HIF-3-alpha
    Cat.:
    U10271h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse HIF-3-alpha
    Cat.:
    U10271r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Mouse HIF-3-alpha
    Cat.:
    P10271Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse HIF-3-alpha
    Cat.:
    P10271Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse HIF-3-alpha
    Cat.:
    P10271Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse HIF-3-alpha
    Monoclonal Antibody for Mouse HIF-3-alpha
    Monoclonal Antibody for Mouse HIF-3-alpha
    Protein for Mouse HIF-3-alpha
    Protein for Mouse HIF-3-alpha
    Protein for Mouse HIF-3-alpha

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    References
    1. 1.
      "Molecular characterization and chromosomal localization of a third alpha-class hypoxia inducible factor subunit, HIF3alpha."
      Gu Y.Z. , Moran S.M. , Hogenesch J.B. , Wartman L. , Bradfield C.A.
      Gene Expr.7:205-213(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1);FUNCTION;TISSUE SPECIFICITY;INTERACTION WITH ARNT
    2. 2.
      "Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression."
      Makino Y. , Cao R. , Svensson K. , Bertilsson G. , Asman M. , Tanaka H. , Cao Y. , Berkenstam A. , Poellinger L.
      Nature414:550-554(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);TISSUE SPECIFICITY;INTERACTION WITH HIF1A
      strain: C57BL/6J.
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: C57BL/6J.
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Brain.
    5. 5.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 193-662 (ISOFORM 1)
      strain: C57BL/6J.
      tissue: Brain.
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